Please use this identifier to cite or link to this item: http://ena.lp.edu.ua:8080/handle/ntb/51770
Title: The Expression of Pleiotropic and Pathway-Specific Regulators of Secondary Metabolism in Clorobiocin Producer Streptomyces Roseochromogenes NRRL3504
Authors: Melnyk, Sofiia
Ostash, Bohdan
Affiliation: Ivan Franko National University of Lviv
Bibliographic description (Ukraine): Melnyk S. The Expression of Pleiotropic and Pathway-Specific Regulators of Secondary Metabolism in Clorobiocin Producer Streptomyces Roseochromogenes NRRL3504 / Sofiia Melnyk, Bohdan Ostash // Litteris et Artibus : proceedings, 23–25 November 2018, Lviv. — Lviv : Lviv Politechnic Publishing House, 2018. — P. 218–219. — (7th International academic conference “Chemistry & chemical technology 2018” (CCT-2018)).
Bibliographic description (International): Melnyk S. The Expression of Pleiotropic and Pathway-Specific Regulators of Secondary Metabolism in Clorobiocin Producer Streptomyces Roseochromogenes NRRL3504 / Sofiia Melnyk, Bohdan Ostash // Litteris et Artibus : proceedings, 23–25 November 2018, Lviv. — Lviv : Lviv Politechnic Publishing House, 2018. — P. 218–219. — (7th International academic conference “Chemistry & chemical technology 2018” (CCT-2018)).
Is part of: Litteris et Artibus : proceedings, 2018
Conference/Event: 8th International youth science forum «Litteris et Artibus»
Journal/Collection: Litteris et Artibus : proceedings
Issue Date: 22-Nov-2018
Publisher: Видавництво Львівської політехніки
Lviv Politechnic Publishing House
Place of the edition/event: Львів
Lviv
Temporal Coverage: 23–25 November 2018, Lviv
Keywords: Streptomyces
clorobiocin
AdpA
StrR-like regulators
gyrase inhibitors
Number of pages: 2
Page range: 218-219
Start page: 218
End page: 219
Abstract: Clorobiocin is potent aminocoumarin against resistant pathogens. We describe attempts to improve clorobiocin production via expression of pleiotropic (adpA) and pathway-specific regulatory (cloG, novG) genes in Streptomyces roseochromogenes NRRL3504. Positive influence of adpA on clorobiocin production was revealed. The effects of cloG and novG are under investigation.
URI: http://ena.lp.edu.ua:8080/handle/ntb/51770
ISBN: 978-966-941-294-2
Copyright owner: © Національний університет “Львівська політехніка”, 2018
References (Ukraine): [1] S. Alt, L.A. Mitchenall, A. Maxwell and L. Heide. “Inhibition of DNA gyrase and DNA topoisomerase IV of Staphylococcus aureus and Escherichia coli by aminocoumarin antibiotics”. J. Antimicrob. Chemother., vol. 66, pp. 2061-2069, 2011.
[2] F. Pojer, S.M. Li, and L. Heide. “Molecular cloning and sequence analysis of the clorobiocin biosynthetic gene cluster: new insights into the biosynthesis of aminocoumarin antibiotics”. Microbiology, vol. 148, no. 12, pp. 3901-3911, 2002.
[3] L. Heide. “The aminocoumarins: biosynthesis and biology”. Nat. Prod. Rep., vol. 26, no. 10, pp. 1241-1250, 2009.
[4] G. Liu, K.F. Chater, G. Chandra, G. Niu and H. Tan. “Molecular regulation of antibiotic biosynthesis in Streptomyces”. Microbiol. Mol. Biol. Rev., vol. 77, no. 1, pp. 112-143, 2013.
References (International): [1] S. Alt, L.A. Mitchenall, A. Maxwell and L. Heide. "Inhibition of DNA gyrase and DNA topoisomerase IV of Staphylococcus aureus and Escherichia coli by aminocoumarin antibiotics". J. Antimicrob. Chemother., vol. 66, pp. 2061-2069, 2011.
[2] F. Pojer, S.M. Li, and L. Heide. "Molecular cloning and sequence analysis of the clorobiocin biosynthetic gene cluster: new insights into the biosynthesis of aminocoumarin antibiotics". Microbiology, vol. 148, no. 12, pp. 3901-3911, 2002.
[3] L. Heide. "The aminocoumarins: biosynthesis and biology". Nat. Prod. Rep., vol. 26, no. 10, pp. 1241-1250, 2009.
[4] G. Liu, K.F. Chater, G. Chandra, G. Niu and H. Tan. "Molecular regulation of antibiotic biosynthesis in Streptomyces". Microbiol. Mol. Biol. Rev., vol. 77, no. 1, pp. 112-143, 2013.
Content type: Conference Abstract
Appears in Collections:Litteris et Artibus. – 2018 р.



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