Please use this identifier to cite or link to this item: http://ena.lp.edu.ua:8080/handle/ntb/46407
Title: Синтез деяких фосфоровмісних похідних поліетиленгліколів
Other Titles: Synthesis of some phosphorus-containing derivatives of polyethylene glycols
Authors: Стасюк, А. В.
Дронь, І. А.
Хом’як, С. В.
Гевусь, О. І.
Самарик, В. Я.
Stasiuk, A. V.
Dron, I. A.
Khomyak, S. V.
Hevus, O. I.
Samaryk, V. Y.
Affiliation: Національний університет “Львівська політехніка”
Lviv Polytechnic National University
Bibliographic description (Ukraine): Синтез деяких фосфоровмісних похідних поліетиленгліколів / А. В. Стасюк, І. А. Дронь, С. В. Хом’як, О. І. Гевусь, В. Я. Самарик // Chemistry, Technology and Application of Substances. — Lviv : Lviv Politechnic Publishing House, 2019. — Том 2. — № 2. — С. 18–24.
Bibliographic description (International): Synthesis of some phosphorus-containing derivatives of polyethylene glycols / A. V. Stasiuk, I. A. Dron, S. V. Khomyak, O. I. Hevus, V. Y. Samaryk // Chemistry, Technology and Application of Substances. — Lviv : Lviv Politechnic Publishing House, 2019. — Vol 2. — No 2. — P. 18–24.
Is part of: Chemistry, Technology and Application of Substances, 2 (2), 2019
Issue: 2
Issue Date: 28-Feb-2019
Publisher: Lviv Politechnic Publishing House
Lviv Politechnic Publishing House
Place of the edition/event: Lviv
Lviv
Keywords: поліфосфатестери
етилдихлорфосфат
тритиловий естер поліетиленгліколю
захист гідроксильної групи
поверхнева активність
polyphosphatester
ethyldichlorophosphate
polyethylene glycol trityl ether
hydroxyl group protection
surface activity
Number of pages: 7
Page range: 18-24
Start page: 18
End page: 24
Abstract: Постадійно розглянуто метод одержання поліетиленглікольетилфосфату. Синтезували цей продукт через взаємодію монозахищеного поліетиленгліколю з фосфор (V) оксихлоридом, в якого попередньо був заміщений один хлор. Показано, що найбільш проблемною стадією із низьким виходом є синтез етилдихлорфосфату. Продукти на кожній стадії охарактеризовували елементним аналізом, кількістю гідроксильних груп, ІЧ-спектроскопією і 31Р ЯМР-спектроскопією за необхідності. Досліджено поверхнево- активні властивості синтезованого поліетиленглікольетилфосфату.
The article is showing the method of obtaining polyethylene glycol ethylphosphate. Synthesis of this product was carried out through the interaction of mono-protected polyethylene glycol with phosphorus (V) oxychloride, in which one of chlorine was substituted. The most problematic stage with low yield, which is the synthesis of ethyldichlorophosphate, is described. At each stage the products were characterized by elemental analysis, the number of hydroxyl groups, IR spectroscopy and 31P NMR spectroscopy, if it was necessary. The surface-active properties of synthesized polyethylene glycol ethylphosphate have been investigated.
URI: http://ena.lp.edu.ua:8080/handle/ntb/46407
Copyright owner: © Національний університет „Львівська політехніка“, 2019
References (Ukraine): 1. Bauer K. N., Tee H. T., Velencoso M. M., Wurm F. R. (2017). Main-chain poly(phosphoester)s: history, syntheses, degradation, bio-and flame-retardant applications. Progress in Polymer Science, 73, 61-122.
2. Wang Z.-Y., Li X.-W., Li J.-N., Li G.-M., Tao J.-Q. (2009). Synthesis of poly(lactic acid)-poly(phenyl phosphate) via direct polycondensation and its characterization. Journal of Polymer Research, 16(3), 255-261.
3. Wang Y.-C., Yuan Y.-Y., Du J.-Z., Yang X.-Z., Wang J. (2009). Recent progress in polyphosphoesters: from controlled synthesis to biomedical applications. Macromolecular Bioscience, 9(12), 1154-1164.
4. Zhao, Z., Wang, J., Mao, H.-Q. & Leong, K. W. (2003). Polyphosphoesters in drug and gene delivery. Advanced Drug Delivery Reviews, 55(4), 483-499.
5. Chaubal M. V., Wang B., Su G., Zhao Z. (2003) Compositional analysis of biodegradable polyphosphoester copolymers using NMR spectroscopic methods. Journal of Applied Polymer Science, 90, 4021– 4031.
6. Clément, B., Grignard, B., Koole, L., Jérôme, C., Lecomte, P. (2012). Metal-free strategies for the synthesis of functional and well-defined polyphosphoesters. Macromolecules, 45(11), 4476-4486.
7. Nagornyak M., Figurka N., Samaryk V., Varvarenko S., Ferens M., Oleksa V. (2016). Modification of polysaccharides by N-derivatives of glutamic acid using Steglich reaction. Chemistry & Chemical Technology, 10(4), 423-427.
8. Varvarenko S. M., Nosova N. Н., Dron I. A., Voronov A. S., Fіhurka N. V., Tarnavchyk I. T., Taras R. S., Vostres V. B., Samaryk V. Y., Voronov S. A. (2013). Novi amfifilni aminofunktsiini poliestery ta dyspersni systemy na yikh osnovi. Voprosy khymyy y khymycheskoi tekhnolohyy, № 5, 27-32.
9. Varvarenko S. M., Fihurka N. V., Samaryk V. Y., Voronov A. S., Tarnavchyk I. T., Dron I. A., Nosova N. H., Voronov S. A. (2013). Novi amfifilni poliestery psevdopoliaminokysloty na osnovi pryrodnykh dvoosnovnykh aminokyslot i dioliv, otrymani reaktsiieiu eteryfikatsii Stehlikha. Polimernyi zhurnal, No. 3, 282-290.
10. Syhhya S., Khanna Dzh.H. (1983). Kolychestvennыi orhanycheskyi analyz po funktsyonalnыm hruppam. Moskva, Khimiia.
11. Toroptseva A. M., Belohorodskaia K. V., Bondarenko V. M. (1976). Laboratornyi praktykum po khymyy y tekhnolohyy vysokomolekuliarnykh soedynenyi. Leninhrad, Khimiia.
12. Galadzhun Y. I., Borzenkov M. M., Hevus O. I. (2012). Syntez novykh poverkhneao-aktyvnykh pokhidnykh polietylenhlikolfosfativ. Khimiia, tekhnolohiia rechovyn ta yikh zastosuvannia, reaktsiieiu eteryfikatsii Stehlikha. Polimernyi zhurnal, No 726, 66-70.
13.Wang D.-Y., Song Y.-P., Lin L.,Wang X.-L.,Wang Y.-Z. (2011). A novel phosphorus-containing poly(lactic acid) toward its flame retardation. Polymer, 52(2), 233-238.
14. Narendran N., Kishore K.(2002). Hydrolytic degradation and diffusion studies on a polyphosphate ester. Journal of Applied Polymer Science, 84(4), 701-708.
15. Fieser L., Fieser M. (1970). Reahenty dlia orhanycheskoho synteza. Moskva, Myr.
References (International): 1. Bauer K. N., Tee H. T., Velencoso M. M., Wurm F. R. (2017). Main-chain poly(phosphoester)s: history, syntheses, degradation, bio-and flame-retardant applications. Progress in Polymer Science, 73, 61-122.
2. Wang Z.-Y., Li X.-W., Li J.-N., Li G.-M., Tao J.-Q. (2009). Synthesis of poly(lactic acid)-poly(phenyl phosphate) via direct polycondensation and its characterization. Journal of Polymer Research, 16(3), 255-261.
3. Wang Y.-C., Yuan Y.-Y., Du J.-Z., Yang X.-Z., Wang J. (2009). Recent progress in polyphosphoesters: from controlled synthesis to biomedical applications. Macromolecular Bioscience, 9(12), 1154-1164.
4. Zhao, Z., Wang, J., Mao, H.-Q. & Leong, K. W. (2003). Polyphosphoesters in drug and gene delivery. Advanced Drug Delivery Reviews, 55(4), 483-499.
5. Chaubal M. V., Wang B., Su G., Zhao Z. (2003) Compositional analysis of biodegradable polyphosphoester copolymers using NMR spectroscopic methods. Journal of Applied Polymer Science, 90, 4021– 4031.
6. Clément, B., Grignard, B., Koole, L., Jérôme, C., Lecomte, P. (2012). Metal-free strategies for the synthesis of functional and well-defined polyphosphoesters. Macromolecules, 45(11), 4476-4486.
7. Nagornyak M., Figurka N., Samaryk V., Varvarenko S., Ferens M., Oleksa V. (2016). Modification of polysaccharides by N-derivatives of glutamic acid using Steglich reaction. Chemistry & Chemical Technology, 10(4), 423-427.
8. Varvarenko S. M., Nosova N. N., Dron I. A., Voronov A. S., Fihurka N. V., Tarnavchyk I. T., Taras R. S., Vostres V. B., Samaryk V. Y., Voronov S. A. (2013). Novi amfifilni aminofunktsiini poliestery ta dyspersni systemy na yikh osnovi. Voprosy khymyy y khymycheskoi tekhnolohyy, No 5, 27-32.
9. Varvarenko S. M., Fihurka N. V., Samaryk V. Y., Voronov A. S., Tarnavchyk I. T., Dron I. A., Nosova N. H., Voronov S. A. (2013). Novi amfifilni poliestery psevdopoliaminokysloty na osnovi pryrodnykh dvoosnovnykh aminokyslot i dioliv, otrymani reaktsiieiu eteryfikatsii Stehlikha. Polimernyi zhurnal, No. 3, 282-290.
10. Syhhya S., Khanna Dzh.H. (1983). Kolychestvennyi orhanycheskyi analyz po funktsyonalnym hruppam. Moskva, Khimiia.
11. Toroptseva A. M., Belohorodskaia K. V., Bondarenko V. M. (1976). Laboratornyi praktykum po khymyy y tekhnolohyy vysokomolekuliarnykh soedynenyi. Leninhrad, Khimiia.
12. Galadzhun Y. I., Borzenkov M. M., Hevus O. I. (2012). Syntez novykh poverkhneao-aktyvnykh pokhidnykh polietylenhlikolfosfativ. Khimiia, tekhnolohiia rechovyn ta yikh zastosuvannia, reaktsiieiu eteryfikatsii Stehlikha. Polimernyi zhurnal, No 726, 66-70.
13.Wang D.-Y., Song Y.-P., Lin L.,Wang X.-L.,Wang Y.-Z. (2011). A novel phosphorus-containing poly(lactic acid) toward its flame retardation. Polymer, 52(2), 233-238.
14. Narendran N., Kishore K.(2002). Hydrolytic degradation and diffusion studies on a polyphosphate ester. Journal of Applied Polymer Science, 84(4), 701-708.
15. Fieser L., Fieser M. (1970). Reahenty dlia orhanycheskoho synteza. Moskva, Myr.
Content type: Article
Appears in Collections:Chemistry, Technology and Application of Substances. – 2019. – Vol. 2, No. 2



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