Please use this identifier to cite or link to this item: http://ena.lp.edu.ua:8080/handle/ntb/20001
Title: Investigation of neighbour group effects in releasing of 5-aminosicylic acid from acrylic polymeric prodrugs
Authors: Babzadeh, Mirzaagha
Naserian, Sona
Bibliographic description (Ukraine): Babzadeh N. Investigation of neighbour group effects in releasing of 5-aminosicylic acid from acrylic polymeric prodrugs / Mirzaagha Babzadeh, Sona Naserian // Хімія та хімічні технології : матеріали ІI Міжнародної конференції молодих вчених CCT-2011, 24–26 листопада 2011 року, Україна, Львів / Національний університет "Львівська політехніка". – Львів : Видавництво Львівської політехніки, 2011. – С. 172–173. – (3-й Міжнародний молодіжний фестиваль науки "Litteris et Artibus"). – Bibliography: 5 titles.
Issue Date: 2011
Publisher: Видавництво Львівської політехніки
Keywords: 5-aminoslicylic acid
polymeric prodrug
acrylic polymeric
2-hydroxypropyl methacrylate
Abstract: Acrylic-type polymeric systems having degradable ester bonds linked to 5-ASA were synthesized and evaluated az materials for drug delivery. prodrugs. 5-aminosalicylic acid (5-ASA) was linked to 2-hydroxypropyl methacrylate by carbonyldiimidazole (CDI) to obtain metachryloyloxy propyl 5-amino salicylate. The resulting acrylic derivative of 5-ASA was copolymerized with 2-hydroxyethyl methacrylat, methyl metacrylat and 2-ethylh hexyl acrylate (in 1:3 mole ratio) by free radical polymerization method in N,N-dimethyl formamid solution, utilizing benzoyl peroxide as an initiator at 70 °C. The obtained polymer was characterized by FT-IR .Gel permeation chromatography was used for determination of average molecular weights of polymers bearing drug units as side substituents of the acrylic backbone. Release studies of 5-ASA were performed into dialysis bags by hydrolysis buffered solutions (pH 1, 7.4, 10) at 37 ºC . Detection of hydrolysis by UV spectroscopy at selected interval showed that the drug can be released by selective hydrolysis of the ester bond at the side of drug moiety. The release profiles indicated that the hydrolytic behavior of polymeric prodrugs is strongly based on the hydrophobicity of polymer and the pH of the hydrolysis solution.
URI: http://ena.lp.edu.ua:8080/handle/ntb/20001
Content type: Article
Appears in Collections:Хімія та хімічні технології (CCT-2011). – 2011 р.

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